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Table of Contents
PART I FUNDAMENTAL ALGORITHMS AND METHODS OF
MEDICAL INFORMATICS
Chapter 1 Parsing and Transforming Text Files
Peeking into Large Files
Paging through Large Text Files
Extracting Lines that Match a Regular Expression
Changing Every File in a Subdirectory
Counting the Words in a File
Making a Word List with Occurrence Tally
Using Printf Formatting Style
Chapter 2 Utility Scripts
Random Numbers
Converting Non-ASCII to Base64 ASCII
Creating a Universally Unique Identifier
Splitting Text into Sentences
One-Way Hash on a Name
One-Way Hash on a File
A Prime Number Generator
Chapter 3 Viewing and Modifying Images
Viewing a JPEG Image
Converting between Image Formats
Batch Conversions
Drawing a Graph from List Data
Drawing an Image Mashup
Chapter 4 Indexing Text
ZIPF Distribution of a Text File
Preparing a Concordance
Extracting Phrases
Preparing an Index
Comparing Texts Using Similarity Scores
PART II MEDICAL DATA RESOURCES
Chapter 5 The National Library of Medicine's
Medical Subject Headings (MeSH )
Determining the Hierarchical Lineage for MeSH Terms
Creating a MeSH Database
Reading the MeSH Database
Creating an SQLite Database for MeSH
Reading the SQLite MeSH Database
Chapter 6 The International Classification of Diseases
Creating the ICD Dictionary
Building the ICD-O (Oncology) Dictionary
Chapter 7 SEER: The Cancer Surveillance, Epidemiology, and End Results Program
Parsing the SEER Data Files
Finding the Occurrences of All Cancers in the SEER Data Files
Finding the Age Distributions of the Cancers in the
SEER Data Files
Chapter 8 OMIM: The Online Mendelian Inheritance in Man
Collecting the OMIM Entry Terms
Finding Inherited Cancer Conditions
Chapter 9 PubMed
Building a Large Text Corpus of Biomedical Information
Creating a List of Doublets from a PubMed Corpus
Downloading Gene Synonyms from PubMed
Downloading Protein Synonyms from PubMed
Chapter 10 Taxonomy
Finding a Taxonomic Hierarchy
Finding the Restricted Classes of Human Infectious Pathogens
Chapter 11 Developmental Lineage Classification and Taxonomy of Neoplasms
Building the Doublet Hash
Scanning the Literature for Candidate Terms
Adding Terms to the Neoplasm Classification
Determining the Lineage of Every Neoplasm Concept
Chapter 12 U.S. Census Files
Total Population of the United States
Stratified Distribution for the U.S. Census
Adjusting for Age
Chapter 13 Centers for Disease Control and Prevention Mortality Files
Death Certificate Data
Obtaining the CDC Data Files
How Death Certificates Are Represented in Data Records
Ranking, by Number of Occurrences, Every Condition in the CDC Mortality Files
PART III PRIMARY TASKS OF MEDICAL INFORMATICS
Chapter 14 Autocoding
A Neoplasm Autocoder
Recoding
Chapter 15 Text Scrubber for Deidentifyin g Confidential Text
Chapter 16 Web Pages and CGI Scripts
Grabbing Web Pages
CGI Script for Searching the Neoplasm Classification
Chapter 17 Image Annotation
Inserting a Header Comment
Extracting the Header Comment in a JPEG Image File
Inserting IPTC Annotations
Extracting Comment, EXIF, and IPTC Annotations
Dealing with DICOM
Finding DICOM Images
DICOM-to-JPEG Conversion
Chapter 18 Describing Data with Data, Using XML
Parsing XML
Resource Description Framework (RDF)
Dublin Core Metadata
Insert an RDF Document into an Image File
Insert an Image File into an RDF Document
RDF Schema
Visualizing an RDF Schema with GraphViz
Obtaining GraphViz
Converting a Data Structure to GraphViz
PART IV MEDICAL DISCOVERY
Chapter 19 Case Study: Emphysema Rates
Chapter 20 Case Study: Cancer Occurrence Rates
Chapter 21 Case Study: Germ Cell Tumor Rates across Ethnicities
Chapter 22 Case Study: Ranking the Death-Certifying Process, by State
Chapter 23 Case Study: Data Mashups for Epidemics
Tally of Coccidioidomycosis Cases by State
Creating the Map Mashup
Chapter 24 Case Study: Sickle Cell Rates
Chapter 25 Case Study: Site-Specific Tumor Biology
Anatomic Origins of Mesotheliomas
Mesothelioma Records in the SEER Data Sets
Graphic Representation
Chapter 26 Case Study: Bimodal Tumors
Chapter 27 Case Study: The Age of Occurrence of Precancers
Epilogue for Healthcare Professionals and Medical Scientists
Appendix